A statistical parameter used in calculating BLAST scores that can be thought of as a natural scale for scoring system. The value lambda is used in converting a raw score (S) to a bit score (S′)....[继续阅读]

    1.蛋白质结构分类及其术语一般情况下,蛋白质的结构分为4个层次:一级结构——蛋白质序列水平,跨膜结构、抗原等;二级结构——α 螺旋和β 折叠模式;三级结构——残基在空间的布局;四级结构——蛋白质之间的互作。蛋白质的一级...[继续阅读]

    Simple sequence repeat,a sequence consisting largely of a tandem repeat of a specific k-mer(such as (CA)15). Many SSRs are polymorphic and have been widely used in genetic mapping....[继续阅读]

    Organizes nodes into sequence layers in which the nodes in each layer are fully connected with the nodes in the next layer,except for the final output layer. Input is fed from the input layer through the layers in sequence in a “feed-forward” direction,re...[继续阅读]

    A chromosome translocation is a chromosome abnormality caused by rearrangement of parts between nonhomologous chromosomes. A gene fusion may be created when the translocation joins two otherwise-separated genes....[继续阅读]

    Population of identical cells or molecules (e.g. DNA),derived from a single ancestor....[继续阅读]

    对于一个基因组给定的K-mer,就有4K 种不同的字符串,为了反映每种字符串的数量,可以把每个字符串数量排在一个2K ×2K 的方块中(图2-1.12上),这样的方阵称为K 框架。对于不同大小的基因组和K-mer,可以使用同样大小的K 框架。由于一个特...[继续阅读]

    The PSSM gives the logodds score for finding a particular matching amino acid in a target sequence. It represents the variation found in the columns of an alignment of a set of related sequences. Each subsequent matrix column corresponds to the next colum...[继续阅读]

    A single sequence that represents,at each subsequent position,the variation found within corresponding columns of a multiple sequence alignment....[继续阅读]

    An efficient and high-throughput technique used to analyze the genome-wide methylation profiles on a single nucleotide level. This technique combines restriction enzymes and bisulfite sequencing in order to enrich the areas of the genome that have a high ...[继续阅读]