23.2.1　FollicularatresiainnormalestrouscyclesOnday1afterovulation,therewereveryfewhealthyantralfolliclesintheovaries,andthenewcorporaluteawereobserved.Amassofdeadgranulosacellsseparatedfromthegranulosalayersandscatteredintheantrum.Furthermore,insomeatreti...[继续阅读]

    Inallfourratmodels,oneovaryofeachexperimentalanimalwereusedforhistologicalexaminationandtheotherovarywashomoginizedforRIAofcGMPlevelsandcGMP-PDEactivities.26.2.1　HistologicalexaminationOurmorphologicexaminationsoftheneonatalratovaryareidenticaltoourprevio...[继续阅读]

    Inthepresentstudy,wemakeacaseforcleavageofPARP-1beingstronglyimplicatedinporcinefolliculardevelopmentandatresiaoffetal,neonatalandadultporcineovaries.WedemonstratedthatPARP-1cleavagemightplayanimportantroleduringtheprocessoffolliculardevelopmentandatresia...[继续阅读]

    目前的研究已经表明PI3K是PKB的上游信号分子,调控PKB信号通路的生理功能[8]。最近的研究也发现FoxO3a是PKB下游的一个重要信号分子,在卵巢功能调节中具有非常重要的调控作用。由此可见,PI3K/FoxO3a通路是调控哺乳动物卵巢卵泡发育的...[继续阅读]

    GnRH神经元是HPG轴的主要调控者,腺垂体以脉冲的方式分泌GTH,包括FSH和LH。这两种激素能够作用于性腺,并促进性腺的发育和类固醇激素的分泌。性腺类固醇在大脑中的作用主要表现为GnRH的反馈调节与性行为的助长。激素和生长因子...[继续阅读]

    25.1.1　AnimalsandexperimentaldesignSprague-Dawleyrats(QinglongshanExperimentalAnimalSupplyCo.,Ltd.,Nanjing,P.R.China)wereusedinthepresentstudy.Theanimalsweremaintainedundera14-hlight(0500～1900h)/10-hdarkschedulewithfoodandwateravailableadlibitum.Theexperi...[继续阅读]

    [1]GARRIDOAM,GRIENDLINGKK.NADPHoxidasesandangiotensinⅡreceptorsignaling.MolCellEndocrinol,2009,302(2):148-158.[2]ZHANGC,HUJJ,XIAM,etal.Redoxsignalingvialipidraftclusteringinhomocysteine-inducedinjuryofpodocytes.BiochimBiophysActa,2010,1803(4):482-491.[3]Z...[继续阅读]

    Toourknowledge,thisstudyisthefirsttodemonstratethatthreeisoformsofNOSandsGCsubunitsinporcinefetalandneonatalovariesduringfollicularformationanddevelopment.Ourresultsclearlyshowcell-specificexpressionofthesethreeNOSisoformsandsGCsubunits.Inaddition,activit...[继续阅读]

    在哺乳动物中,生殖激素能够调控卵巢功能,其中气体信号分子NO信号通路在这个调节过程中起了非常重要的作用。目前的研究已经表明NO是通过NOS生成的,而且NOS受到多种细胞因子和生殖激素的调控,如AngⅡ、FSH和hCG等。进一步研究还发...[继续阅读]

    [1]RICHARDSJS,FITZPATRICKSL,CLEMENSJW,etal.Ovariancelldifferentiation:acascadeofmultiplehormones,cellularsignals,andregulatedgenes.RecentProgHormRes,1995,50:223-254.[2]AHARONID,DANTESA,ORENMetal.cAMP-mediatedsignalsasdeterminantsforapoptosisinprimarygranu...[继续阅读]