Circulatinginflammatoryfactorsassociatedwithworselong-termprognosisincolorectalcancer

摘要： AIMToinvestigateassociationofcirculatinginflammatoryfactorsatthetimeofcolorectalcancer(CRC)surgerywithsurvival.METHODSPlasmalevelsfrom174CRCpatients(69femalesand105men),withmedianage70years(range29-90),localizedinthecolon(n=105)orrectum(n=69),withstageⅠ(n=24),stageⅡ(n=54),stageⅢ(n=67)andstageⅣ(n=29)weremeasuredusingcommerciallyavailableBio-PlexPro?HumanChemokinePanel40-Plex,including40differentchemokines,cytokinesandinterleukins.TheprognosticassociationofeachinflammatoryfactorwasanalysedasCRC-specificandtotalmortality.RESULTSOutof174patients,66diedduringthefollow-up,40becauseofCRCspecificmortality.Hightertilelevelsof8factorsweresignificantlyassociatedwithincreasedCRC-specificmortality,ofwhichCCL1,CCL20,CCL24,CX3CL1,IL-4andTNF-αremainedsignificantinamultivariateCoxregressionanalysis.Hightertilelevelsof14factorswereassociatedwithincreasedtotalmortality,ofwhichCCL1,CCL15,CCL20,CX3CL1,CXCL13,IFN-γ,IL-2,IL-4andIL-10remainedsignificantafteradjustmentforclinicalcovariates.Formostoftheinflammatoryfactorstheassociationbetweenhighertertilelevelsandanincreasedmortalityingeneralappearedtwoyearsaftersurgery.HightertilelevelsofTNF-αandCCL24wereexclusivelyassociatedwithCRC-specificmortality.ThedistributionofthesefactorswerenotassociatedwithTNMstagewithexceptionforCCL20.CONCLUSIONHighplasmalevelsofinflammatoryfactorsareassociatedwithincreasedriskofmortalityamongCRCpatientsandcouldbepotentialbiomarkersforrevealingprognosis. ... （共8页）