SubcellularlocalizationofRhoGTPases:implicationsforaxonregeneration
摘要: Damagetoneuronsinthecentralnervoussystemoftenleadstoapermanentlossoffunctionduetoseveralfactors,includingreducedcapacityofaxonstoregenerateandanenvironmentthatinhibitsaxonregenerationbecauseofdisruptionofmyelinandtheformationofagrowth-refractoryglialscararoundtheinjury(YoonandTuszynski,2012).Strategiestopromoteaxonregenerationincludebothincreasingthecapacityofcentralnervoussystemaxonstoregenerate,aswellaslimitingthepost-insultinhibitoryenvironment(Gordon-WeeksandFournier,2014).Damagedcentralnervoussystemneuronsdoretainsomeintrinsiccapacitytoregenerate.Ifthisabilitycouldbeenhanced,axonregenerationandre-connectiontoappropriatetargetscould ...
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