Clinicalasthmaphenotyping:Atrialforbridginggapsinasthmamanagement
摘要: Asthmaisacommondiseaseaffectingmillionsofpeopleworldwideandexertinganenormousstrainonhealthresourcesinmanycountries.Evidenceisincreasingthatasthmaisunlikelytobeasinglediseasebutratheraseriesofcomplex,overlappingindividualdiseasesorphenotypes,eachdefinedbyitsuniqueinteractionbetweengeneticandenvironmentalfactors.Asthmaphenotypeswereinitiallyfocusedoncombinationsofclinicalcharacteristics,buttheyarenowevolvingtolinkpathophysiologicalmechanismtosubtypesofasthma.Bettercharacterizationofthosephenotypesisexpectedtobemostusefulforallocatingasthmatherapies.Thisarticlereviewsdifferentpublishedresearchesintermsofunbiasedapproachestophenotypeasthmaandemphasizeshowthephenotypingexerciseisanimportantsteptowardsproperasthmatreatment.Itisstructuredintothreesections;theheterogeneityofasthma,theimpactofasthmaheterogeneityonasthmamanagementanddifferenttrialsforphenotypingasthma. ...
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