Storagelesion:Historyandperspectives
摘要: Redbloodcellconcentrates(RBCCs)arethemajorlabilebloodcomponenttransfusedworldwidetorescuesevereanemiasymptoms.RBCCsarefrequentlystoredinadditivesolutionsat4℃forupto42d,whichinducescellularlesionandaltersredbloodcellmetabolism,proteincontent,andrheologicalproperties.Thereexistsahotdebatesurroundingtheimpactofstoragelesion,withsomeuncertaintyregardinghowRBCCagemayimpacttransfusion-relatedadverseclinicaloutcomes.Severalstudiesshowatendencyforpooreroutcomestooccurinpatientsreceivingolderbloodproducts;however,noclearsignificantassociationhasyetbeendemonstrated.Someage-relatedRBCCalterationsprovereversible,whileotherchangesareirreversiblefollowingproteinoxidation.Itislikelythatanyirreversibledamageaffectsthebloodcomponentqualityandthusthetransfusionefficiency.Thepresentpaperaimstopromoteabetterunderstandingoftheoccurrenceofredbloodcellstoragelesion,withparticularfocusonbiochemicalchangesandmicrovesiculation,throughadiscussionofthehistoricaladvancementofbloodtransfusionprocesses. ...
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