当前位置:首页 > 医学文档 > 肿瘤学 > 正文

Helicobacter,gamma-glutamyltransferaseandcancer:Furtherintriguingconnections

WorldJournalofGastroenterology 页数: 2 2014-12-21
摘要: VirulenceofHelicobacterpylori,Helicobactersuisandotherbacteriaappearstobepartlymediatedthroughareleaseofgamma-glutamyltransferase(GGT),anenzymeactivitycapableofpromotingbiochemicalreactionsultimatelyresultingindamagetogastricepitheliumandsuppressionofimmuneresponse.RecentlypublishedstudiesshowthatsecretionofbacterialGGToccursintheformofexosome-likevesicles.VerysimilarGGT-richexosomeshavebeendescribedtooriginatefromhumancancercells,andthehypothesisisthusforwardedthatintheresistantandinvasivephenotypeofmalignantcellssuchvesicular/exosomalGGTmayplayrolesakintothosedescribedforHelicobacterinfection,thusprovidingasignificantcontributiontotheestablishmentofcancermetastases. ... (共2页)

开通会员,享受整站包年服务
说明: 本文档由创作者上传发布,版权归属创作者。若内容存在侵权,请点击申诉举报