Helicobacter,gamma-glutamyltransferaseandcancer:Furtherintriguingconnections
摘要: VirulenceofHelicobacterpylori,Helicobactersuisandotherbacteriaappearstobepartlymediatedthroughareleaseofgamma-glutamyltransferase(GGT),anenzymeactivitycapableofpromotingbiochemicalreactionsultimatelyresultingindamagetogastricepitheliumandsuppressionofimmuneresponse.RecentlypublishedstudiesshowthatsecretionofbacterialGGToccursintheformofexosome-likevesicles.VerysimilarGGT-richexosomeshavebeendescribedtooriginatefromhumancancercells,andthehypothesisisthusforwardedthatintheresistantandinvasivephenotypeofmalignantcellssuchvesicular/exosomalGGTmayplayrolesakintothosedescribedforHelicobacterinfection,thusprovidingasignificantcontributiontotheestablishmentofcancermetastases. ...
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