Relationship between plasma D-dimer levels and clinicopathologic parameters in resectable colorectal cancer patients

摘要： <正> AIM:To assess the clinical significance of the D-dimer levelsand the relationship between plasma D-dimer levels andclinicopathologic parameters in operable colorectal cancerpatients.METHODS:The plasma levels of D-dimer were measuredpre-and postoperatively in 35 patients with colorectalcancer,and 30 healthy subjects served as controls by themethod of quantitative enzyme-linked immunosorbentassay (ELISA).RESULTS:The mean preoperative plasma levels of D-dimerin the patients with colorectal cancer (1.06±0.24 mg/L) weresignificantly higher than those of controls (0.33±0.12 mg/L,P<0.01).The D-dimer levels were remarkably elevated onthe 1st day after operation (1.22±0.55 mg/L,P<0.01).Onthe 3rd day the level of D-dimer began to stepwise descendand on the 14~(th) day nearly returned to control level.Thepreoperative Ievels of D-dimer were significantly correlatedwith the Iymph node metastasis and Dukes stage but hadno association with tumor location and the degree ofdifferentiation.A stepwise increase in the mean D-dimerlevels was found with increase of the tumor stage.CONCLUSION:Hypercoagulation and higher fibrinolyticactivities occur in patients with colorectal cancer.Theoperative trauma could enhance the fibrinolysis in thepatients with colorectal cancer.The measurement ofpreoperative D-dimer levels is considered to be useful forpredicting Iymph node metastasis and stage of colorectalcancer. ... （共2页）