Localization of TRAIL/TRAILR in fetal pancreas

摘要： <正> AIM:To observe the localization of TRAIL/TRAIR(DR4,DR5,DcR1,DcR2)in the fetal pancreas.METHODS:Fetal pancreas of 32 weeks of pregnancy wereobtained from induced abortions,embedded in paraffin,and4-μm sections were prepared,The localization of TRAIL/TRAILR in fetal pancreas was investigated by fluorescenceimmunohistochemical method combined with laser scanningconfocal microscopy.RESULTS:TRAIL immunoreactive cells were mainly locatedon the periphery of the pancreas islets.There were a fewDcR1 and DcR2 positive cells whereas there were noimmunoreactive cells of DR4 and DR5 in the pancreas islets.In the acini and the ducts of the exocrine pancreas therewere no TRAIL/TRAILR immunoreactive cells.CONCLUSION:This study not only describes thedistribution of TRAIL/TRAILR in the fetal pancreas,but alsoprovides a morphological basis for deducing the functionof TRAIL/TRAILR in pancreas,suggesting that in normalpancreatic islets,the pancreatic cells are resistant towardsapoptosis too. ... （共4页）