Detection of Copy Number Alteration of MTA1 in Human Breast Cancer

摘要： <正> OBJECTIVE The purpose of our study was to investigatethe expression level of MTA1 mRNA in breast cancer and itssignificance in relation to clinical pathology.METHODS The expression levels of MTA1 rnRNA in tumorand in paired normal adjacent tissue of 56 cases with breast cancerwere detected by fluorescent quantitative polymerase chainreaction.RESULTS The expression of MTA1 mRNA was detected in 47tumor specimens of 56 breast cancer patients(83.9%)and wassignificantly higher than in the paired normal breast tissue.Theover expressed MTA1 mRNA was significantly associated withpathologic stage(P=0.029),clinical grade(P=0.035)and lymphnode status(P=0.001).CONCLUSION The over expression of MTA1 mRNA may playa crucial role in the development of breast cancer.As the MTA1was comparatively highly-expressed in breast cancer,it maybecome a new biomarker for the diagnosis and treatment of breastcancer in the future. ... （共5页）