植物多糖的免疫调节作用及其机制研究进展

【关键词】:植物多糖;;免疫调节;;受体;;信号通路
【摘要】:多糖是生物体内广泛存在且具有多种生物活性的一类天然大分子物质,其对机体免疫系统具有重要调节作用。研究表明,植物多糖可通过与免疫细胞表面的多种受体结合、激活不同的信号通路来调控动物机体的免疫系统,包括:刺激巨噬细胞、T/B淋巴细胞、自然杀伤细胞的分泌或增殖;调节细胞因子的释放;促进抗体的分泌;激活补体系统等。本文主要对植物多糖对动物机体的免疫调节作用及其分子作用机制相关研究进行综述。
Polysaccharides,a kind of natural macromolecule,is widespread occurrence in biological bodies and has many kinds of biological activities,which plays an important role in regulating immune system. Previous studies documented that phytogenic polysaccharides could regulate animals' immune system by combining to membrane receptors of immune cells and initiating the special signaling pathways. This included stimulating the secretion or proliferation of macrophages,T / B lymphocytes and natural killer( NK) cells,modulating the release of cytokines,promoting the production of antibodies,and activating the complement system,etc. This paper mainly reviews the immune regulation roles of phytogenic polysaccharides and related molecular mechanisms.