中国药理学与毒理学杂志(2019年10期)
Chinese Journal of Pharmacology and Toxicology

目 录

• 大会报告
• 医学科技中的伦理道德考量
• Pharmacogenomics in oncology
• Pharmacology and drug discovery
• Metabolic aspects behind ageing and neurodegeneration reveal new ...
• 肿瘤的精准治疗与挑战
• 大脑觉醒及三代促清醒药物
• 青年英文报告和论文摘要_青年学者报告和论文摘要
• Selective and robust UPLC-MS/MS method for simultaneous quantitat...
• Bitter compounds delay gastric emptying while affecting plasma ho...
• A semisynthetic cabazitaxel analogue, C1 overcomes P-gp-meditaed ...
• Low expression programming of angiotensin receptor Ⅱ mediated pa...
• Potential role of histone deacetylase 3 specific inhibitor Compou...
• Artemisinin analogue SM934 protects againstlupus-associated antip...
• Melatonin prevents endothelial cell pyroptosis via regulation of ...
• Multiple circulating saponins from intravenous Shenmai inhibit OA...
• Identification of SPP1 as an extracellular matrix signature for m...
• Acute phase protein orosomucoid protects against heart failure th...
• Mechanistic of Daxiepi Tang in treating lung cancer based on netw...
• Chronic stress alters activity of insular cortex,leading to aberr...
• Remedial dosing recommendations for valproic acid in nonadherence...
• Shenmai injection attenuated doxorubicin-induced cardiac dysfunct...
• Andrographolide derivative as anti-inflammation agent for treatme...
• CP-25 ameliorates progression of animal arthritis model by inhibi...
• Platelet-derived miR-223 promotes a phenotypic switch in arterial...
• Elevated progranulin contributes to synaptic and learning deficit...
• Effects of purified fruit bromelain fractions on intestinal infla...
• Protease-activated receptor 2 modulating cancer cell signal trans...
• Role of pleckstrin-2 in cancer
• Bidirectional modulation of HIF-2 activity through allosteric lig...
• Up-regulated Piezo1 in VSMCs promotes pathological hemodynamic en...
• Effect of proteomics change of PTS on liver tissue potentially in...
• DP1 activation protects against injury-induced vascular neointima...
• RhoC/ROCK2 promotes vasculogenic mimicry formation primarily thro...
• Enhancement of epithelial cell autophagy induced by sinensetin al...
• 青年英文报告和论文摘要_研究生报告和论文摘要
• Kanglexin, a novel anthraquinone compound,protects against myocar...
• LINC00152 upregulates ZEB1 to enhance epithelial-mesenchymal tran...
• Ganoderic acid hinders renal fibrosis via suppressing TGF-β/Smad...
• ROCK1 inhibitor fasudil improves diabetic wound healing via AMPK/...
• Inhibition of P2X7R modulates ECM deposition in HSCs and crosstal...
• Protect dextran sulfate sodium-induced ulcerative colitis in mice...
• Anexploration on potential mechanism of Shanhaidan Granules in tr...
• LncRNA SPRY4-IT1 regulates breast cancer cell stemness through co...
• Nicotinic acetylcholine receptor α7 inhibits platelet-derived gr...
• Continuous culture of urine-derived bladder cancer cells for prec...
• ATF3 promotes ferroptosis by suppressing system Xc~-
• Impact of obese levels on hepatic expression of drug-metabolizing...
• Phosphorylation site at serine 282 of connexin 43 has a regulator...
• Amiodarone induces autophagy/mitophagy by activating sirtuin-3 in...
• Xenon exerts anti-seizure and neuroprotective effects in kainic a...
• Cytochalasins Q and 19, 20-epoxycytochalasin C exhibit anti-tumor...
• Drug repurposing identifies econazole as a novel neuroprotective ...
• Betulinic acid induces apoptotic and autophagic cell death in hep...
• Anti-proliferation activity of total flavonoids isolated from Dio...
• Resistance of esophageal cancer cells to paclitaxel can be reduce...
• Effect of all-trans retinoic acid on differentiation of osteosarc...
• Acanthoic acid modulates lipogenesis in nonalcoholic fatty liver ...
• Inhibition of PDE4 represents an infusive therapeutic strategy in...
• Anovel BTK inhibitor SIMM-016, ameliorates rheumatoid arthritis b...
• Classic herb pair sculellaria barbata and hedyotis diffusa for br...
• Ganodermalucidum polysaccharide peptides attenuate post myocardia...
• Ginsenoside 25-OCH3-PPD promotes activity of LXRs to ameliorate P...
• Role and mechanism of ORM in adipose tissue fibrosis and insulin ...
• Discovery and utilization of marine leading compounds in tumor im...
• CDK2 suppressionsynergizes with all-transretinoic acid toovercome...
• Roles of Sirtuin family in non-small cell lung cancer
• Lipid metabolic reprogramming promotes hepatocarcinogenesis and t...
• Identification of a clinical compound losmapimod that blocks Lass...
• 专题报告和论文摘要_临床药理学
• 磷酸二酯酶:从伟哥到抗阿尔茨海默病药物
• Evaluation of interventions by pharmacists in vancomycin treatmen...
• Efficacy and safety of different proprotein convertase subtilisin...
• Development of a novel prognostic signature based on antigen proc...
• Associations between polymorphisms of endothelial nitric oxide sy...
• 体医结合对老年前列腺增生症状的改善和生活质量的影响
• 替格瑞洛片在中国健康志愿者空腹和进食条件下的生物等效性研究
• 临床药师对1例青霉素过敏的坏死性筋膜炎合并糖尿病患者的药学服务
• 专题报告和论文摘要_心血管药理学
• TMEM16A在脑血管重构中血管平滑肌细胞迁移的作用机制
• 类脑器官与移植治疗
• 尿素通道蛋白作为利尿和治疗高血压潜在药物靶点的确认和相关药物研发
• Puerarin inhibits hyperglycemia-induced NLRP3 inflammasome activa...
• Sodium ferulate inhibits cardiomyocyte hypertrophy induced by Ang...
• Inflammasome-independent NALP3 contributes to high-salt induced e...
• Roles of Zn~(2+) and mPTP in resveratrol-induced myocardial prote...
• AMPK-ULK1 mediated autophagy contributed to myocardial injury by ...
• Identification of α-enolase phosphorylationsites at Ser268, Tyr2...
• Cyclosporine, but not mycophenolate, increases nitric oxide produ...
• Metrnl increases blood HDL-cholesterol and decreases blood trigly...
• Pathological upregulation of galectin-3 contributes to ischemia/r...
• Salvianolic acid A protects H9C2 cardiomyocytes against hypoxia/r...
• Carvedilol induces biased β1 adrenergic receptor-cGMP signaling ...
• Glycogen synthase kinase-3β inhibition alleviates NLRP3 inflamma...
• LncRNA ACART protects cardiomyocytes from apoptosis by activating...
• Circular RNA circ ASK1 acts as a microRNA-22 sponge to attenuate ...
• Silencing of METTL3 attenuates cardiac fibrosis induced by myocar...
• Endothelial Nlrp3 inflammasome activation is associated with endo...
• Underlying mechanism of athycaltide-1, a novel peptide, ameliorat...
• Aloe-emodin relieve Ang Ⅱ-induced endothelial junction dysfuncti...
• Long noncoding RNAs: emerging players in cardiac electrical and s...
• AMPK-FOXO3a pathway inhibits fibroblast-myofibroblast differentia...
• Role of a new-type polypeptide in regulation of oxidative stress ...
• Inhibition of PKC represses the prolongation of QRS complex in EA...
• Cardio-protective effects of the new crystal of puerarin in isopr...
• Responses of endothelial PP2Acα deficiency towards ischemic cond...
• 新型Rho激酶抑制剂——DL0805-1通过抑制ROCK通路减轻肺动脉高压大鼠肺...
• 心肌细胞缺氧复氧模型的建立方法及能量代谢相关检测指标研究进展
• 硫化氢在抗动脉粥样硬化的研究进展
• 缬沙坦通过GJA1-20k促进缝隙连接形成逆转心肌肥厚
• 细胞内外sFRP1对多柔比星心肌病的不同作用及机制
• 免疫系统异常在孕期炎症刺激致子代动脉粥样硬化发生的作用及机制
• 长链非编码RNA-ZFAS1通过诱发心脏钙超载诱导心肌梗死模型小鼠心肌细胞...
• 蛭芎胶囊工艺变更前后对脑动脉硬化模型大鼠的影响
• 高脂血症与动脉粥样硬化和脂代谢研究进展
• 心脏脂肪酸代谢抑制在孕期炎症刺激致子代小鼠心脏损伤中的作用及机制
• 晶Ⅴ型葛根素对心肌缺血小鼠的药效学研究
• 淫羊藿苷通过调节巨噬细胞极化抑制肺动脉高压血管重构
• 肺动脉高压治疗药物研究进展
• GSK-3β抑制剂下调大鼠心肌梗死后CD47表达的升高
• 共晶物DL1602改善异丙肾上腺素致心衰大鼠心功能的实验研究
• 低氧诱导小鼠肺动脉高压模型的建立
• 慢性肾衰高磷血症诱导的血管钙化与心血管疾病的相关性及防治进展
• 专题报告和论文摘要_药物代谢
• 基因编辑技术创新构建大鼠药物代谢模型及其应用
• Systematic external evaluation of published population pharmacoki...
• Metabolomics study of Shenfu Injection on mid-stage cardiogenic s...
• Evaluation of assays for aminoglycosides in serum:a comparison of...
• Involving nonlinear kinetics to improve predictive performance of...
• No effect of acylpeptide hydrolase polymorphisms on pharmacokinet...
• Population pharmacokinetic modeling for mycophenolic acid and its...
• Metabolomics combined with serum pharmacochemistry discovering ef...
• A CYP716A enzyme function of oleanane oxidase in biosynthesis of ...
• Effect of Chinese herb Danzhi Xiaoyao pills on pharmacokinetics o...
• lncRNA HNF4α-AS1参与调控转录因子和细胞色素CYP450表达
• 甘草酸二铵调节CYP450酶和血浆蛋白结合率对奥美拉唑药代动力学的影响
• UHPLC-MS/MS法测定大鼠血浆中黄芪建中汤13种成分浓度
• HPLC-DAD/MS法测定辛伐他汀滴丸储存中有关物质含量变化
• 基于LC-MS代谢组学的注射用黄芪多糖活性成分对巨噬细胞吞噬活性的影响
• 蓓萨罗丁固体分散体制备及药物代谢动力学检测
• 伊立替康不良反应与UGT1A1基因多态性和血药浓度关系的研究
• DNA甲基化参与PXR介导的CYP3A4的表达
• 平衡透析法结合LC-MS/MS研究奥克梯隆型皂苷元的大鼠血浆蛋白结合率
• 茵陈术附汤挥发性成分在大鼠体内药代动力学研究
• UPLC-MS-MS测定来自中药九里香中九里香酮的血药浓度
• 多种DL1801共晶化合物的大鼠体内药代动力学研究
• 专题报告和论文摘要_教学与科普
• 来华留学临床医学教育面临的问题及对策
• 药理学金课建设
• 失眠机制及药物治疗
• 静脉滴注并不“快”
• 团队自主学习模式在中药药理学教学中的应用
• 专题报告和论文摘要_肾脏药理学
• 肾脏中G蛋白偶联受体信号转导的多样性
• 线粒体:急性肾损伤治疗的新靶标
• FOXO1 inhibition prevents renal ischemia-reperfusion injury via p...
• Petroleum ether extract of Derris eriocarpa How.(PEEDEH) investig...
• Contribution of TFEB-mediated autophagy totubulointerstitial fibr...
• Morin reduce uric acid level in hyperuricemia mice
• 姜黄素对TNF-α诱导人肾小球系膜细胞增殖及PTX3表达的作用研究
• endophilin A2抑制小鼠肾间质纤维化的形成
• 圆锥绣球提取物治疗慢性肾功能不全的临床前开发及药理机制
• 专题报告和论文摘要_民族药物生化与分子机制
• 冠心活血胶囊的药效学研究
• Pharmacological and toxicological studies of famous Chinese medic...
• Melanin homeostasis plays an important role in kaempferide-induce...
• Physcion and physcion 8-O-β-glucopyranoside:a review of their ph...
• 人参皂苷抗氧化应激损伤作用及其作用机制的研究进展
• EGCG的药理作用及作用机制
• 基于网络药理学探讨蒙药锁阳促智作用的物质基础
• 拟黑多刺蚁活性组分药理作用研究进展
• 人参皂苷对细胞自噬信号通路调控作用的研究进展
• 鹿茸胶原酶解物对地塞米松诱导成骨细胞MC3T3-E1凋亡的保护作用
• 紫花地丁烫伤酊治疗大鼠烫伤模型试验
• 蒙药朱日很滴丸对急性心肌缺血的影响
• 基于网络药理学和生物信息学分析桂枝茯苓丸治疗多囊卵巢综合征的作用...
• 基于“活性成分-作用靶点-通路”网络葛根抗缺氧作用生物机制研究
• 蒙药毒性效应及影响因素
• 金钗石斛生物碱对四氯化碳所致小鼠肝线粒体损伤的保护作用及机制
• 专题报告和论文摘要_综合交叉药理学
• Identification of two natural coumarin enantiomers for selective ...
• 小鼠应激易感与耐受模型的建立
• 基于多学科的靶标发现和确证
• 放射性肺纤维化基质重构与肌成纤维细胞凋亡抵抗的相关性
• 药物毒理学的研究进展
• 植物中有机硫化物的提取分离工艺研究进展
• 小鼠骨骼肌表型和性别对饥饿诱导肌肉因子FNDC5表达的影响
• 疽愈喷剂对骨髓炎模型兔骨修复中ADAMTS-7和骨Ⅰ型胶原表达的机制研究
• 苦苣菜药材细粉混悬液安全药理学研究
• 精子优选新方法建立及相关调节机制研究
• NLRP3炎性小体介导曲妥珠单抗增强多柔比星所致心脏毒性的作用
• 丹酚酸A联合低剂量泼尼松对多柔比星诱导的微小病变型肾病的保护作用研究
• 药物依赖性试验方法概述
• 分子药理学研究进展
• 人精子中Slo1和Slo3钾离子通道共同参与调控精子获能过程
• 山萘酚通过抑制伽马辐射诱导的氧化应激和凋亡发生来发挥辐射防护作用
• 我国新药研发的研究进展
• 急性应激障碍向创伤后应激障碍转化模型的建立
• 甘草酸防治雷公藤肝毒性的研究进展
• 新药研发过程中的毒理学
• LW-AFC对~(60)Co射线辐射损伤小鼠预防作用的初步研究
• 新型避孕药的研究进展及其非避孕益处的应用进展
• 专题报告和论文摘要_神经药理学
• Effect of active components group of Xiaoxuming decoction on cere...
• Orexinergic neurons lesion partially prevent hypertension and sle...
• Pharmacological effects of Rg1 in neuropsychopharmacology
• Andrographolide alleviates parkinsonism in MPTP-PD mice via targe...
• Tetramethylpyrazine nitrone improved mitochondrial dysfunction, d...
• Effect of active ingredient of Stephaniajaponica(Thunb.) Mierson ...
• Balance of synaptic and extrasynaptic NMDA receptors play an impo...
• Cornin protects astrocytes against autophagy induced by cerebral ...
• Effects of GBEE on memory impairment induced by scopolamine in mi...
• Ethanol induces sedation and hypnosis via inhibiting histamine re...
• Ethanol increases GABA release in tuberomammillary nucleus but no...
• Increased blood pressure variability induces depression-like beha...
• Research advances in treatment of Alzheimer disease with traditio...
• Anti-aging effect of aqueous extract from Astragalus membranaceus...
• Cerebral organoids repair ischemic stroke brain injury
• Mitochondrial dysfunction and neuroinflammation in Parkinson disease
• Syntaxin 17 inhibits ischemic neuronal injury by enhancing autoph...
• PDE7A expression on alcohol consumption and alcohol withdrawal in...
• Effect of α-asarone on ethanol-induced learning and memory impai...
• Effect of ostholon memory and tau protein phosphorylation in brai...
• P7C3-A20 is not a direct Nampt activator
• Baicalein attenuates neuroinflammation in LPS-activated BV-2 micr...
• Attenuation of cerebral ischemia-reperfusion injury by specific a...
• Drug-target interaction prediction with deep learning
• Functions of connexin-43 in neural development and its relationsh...
• Development of sensitive mass spectrometry methods for qualitativ...
• PPARβ/δ-agonist F3SM and GW501516 ameliorates dysfunction in gl...
• Improving effect and mechanism of fisetin on cell model of diabet...
• Computational systems pharmacology reveals anantiplatelet and neu...
• Role of serotonin signaling in depression-like behavior induced b...
• Matrilin-3 is found in brain and promotes brain functional recove...
• Syb-pr Ⅱ对三叉神经痛大鼠的镇痛作用研究及机制研究
• 姜黄素类似物Cur20的抗痴呆作用
• δ阿片受体转激活EGFR发挥神经保护作用的机制研究
• Rg1和Rb1治疗缺血性卒中的研究进展
• 三萜类化合物的神经药理作用
• 富含脯氨酸的酪氨酸激酶2与突触可塑性
• 岛叶皮质在观察性恐惧习得中的作用
• α-突触核蛋白对帕金森病自我免疫病理的影响
• CKLF1在缺血性卒中中的作用研究进展
• 降钙素基因相关肽在神经性痛大鼠扣带回内的痛觉调节作用及其机制
• 补阳还五汤治疗神经退行性疾病作用机制研究进展
• 孕期地塞米松暴露所致雌性子代大鼠海马谷氨酸能系统和神经行为改变
• 阿尔茨海默病临床治疗策略的研究进展
• 罗替戈汀缓释微球对炎症性疼痛的镇痛作用
• Ⅰ型大麻素受体调控焦亡通路介导抗精神病药心肌毒性的机制
• N-酰基乙醇胺酸性水解酶（NAAA）促进脑皮质挫伤（TBI）中血脑屏障的破坏
• 百可利对鱼藤酮损伤模型小鼠自噬的影响
• 丹酚酸A与阿司匹林预防给药对血脑屏障保护作用的比较
• 小胶质细胞极化在帕金森病中的作用
• 水通道蛋白4参与抑郁症发病机制研究进展
• 线粒体能量代谢障碍在抑郁症发病机制中的关键作用
• 5-脂氧酶及其抑制剂在MPP~+诱导PC12细胞损伤中的作用
• EGCG通过调控胱天蛋白酶介导的NLRP3炎症小体激活抑制LPS+Aβ诱导BV2细...
• 星形胶质细胞-神经元的相关关系研究进展
• 单次皮质酮注射对小鼠情绪症状与认知功能的影响
• 灵芝酸对小鼠局灶性脑缺血再灌注损伤的保护作用及机制研究
• 药物CIG调节tau蛋白磷酸化改善转基因小鼠的tau蛋白病变
• 人参中有效成分对脑缺血再灌注损伤保护作用的研究进展
• 人诱导性多能干细胞源性小胶质细胞诱导方法的建立及其表型和功能的初...
• FAAH/MAGL抑制剂在中枢神经系统疾病治疗中的潜在应用
• 百可利防治多发性硬化症的作用及机制
• 丹酚酸A通过激活Nrf2抗氧化通路同时抑制MMP-9保护血脑屏障共同发挥抗...
• 星形胶质细胞与神经退行性疾病的相关性
• 芳香烃受体对皮质酮致LTP损伤作用影响的初步研究
• 星形胶质细胞焦亡与抑郁症发生的相关性
• 激动NMDA受体甘氨酸位点可改善皮质酮致海马长时程增强损伤
• 脑缺血再灌注神经细胞凋亡机制研究进展
• mTOR信号通路介导姜黄素抗抑郁作用机制
• 靶向垂体库欣病药物治疗研究进展
• 降钙素基因相关肽在大鼠臂旁核内痛觉调节作用的研究
• 缺血性卒中患者基因表达谱的生物信息学分析
• 咔唑类生物碱衍生物CZ-7对cuprizone诱导的动物模型髓鞘再生的影响及机制
• 大株红景天胶囊对小鼠抗疲劳作用研究
• 类脑救治脑创伤的研究
• 急性应激对背、腹侧海马成年神经再生的影响
• 毛蕊花糖苷促进神经递质释放的分子机制
• 柴归颗粒对抑郁模型大鼠行为学及HPA轴的影响
• 代谢组学结合网络药理学技术探讨黄芪-丹参药对预防大鼠脑缺血的药效机制
• MYR通过NF-κκB信号通路改善LPS诱导小鼠纹状体炎症反应
• 低剂量氯胺酮联用丁苯酞对急性抑郁小鼠行为的影响
• 醒脑静注射液对脑出血小鼠神经功能的影响
• SZY改善氧化应激致认知障碍的作用
• NMDA受体在皮质酮介导海马突触可塑性损伤中的作用
• 卒中后中枢疼痛的机制研究进展
• 基于全球上市药物数据的抗阿尔茨海默病重定位新药发现
• 小柴胡汤对围绝经期小鼠抑郁焦虑症状的改善作用及其机制
• exendin-4对Aβ介导的星形胶质细胞炎症反应的改善作用及与NLRP2相关通...
• 中药多糖治疗神经退行性疾病及其机制
• 银杏内酯通过激活Nrf2和CREB核转位促进抗氧化和抗凋亡基因表达发挥抗...
• 植物雌激素抑制线粒体途径凋亡发挥神经保护作用的机制
• 黄芪甲苷的神经保护作用研究进展
• 帕金森病的病因学
• 趋化因子介导脑缺血后神经修复的研究进展
• PPARα促进自噬流抑制脑缺血后星形胶质细胞的过度激活
• 星形胶质细胞多巴胺D2受体通过β-arrestin 2偏爱型通路调控神经炎症
• 专题报告和论文摘要_肿瘤药理学
• Up-regulation of Cx43 expression in exosomessecreted by glioblast...
• Denosumab versus zoledronic acid in prevention of skeletal-relate...
• Both IDO1 and TDO contribute to malignancy of gliomas via Kyn-AhR...
• Description of circRNA-associated-ceRNA networks and potential ro...
• Mechanisms of migration and invasion promoted by NSCLC cells-deri...
• Mechanism of anti-breast cancer compound produced by marine fungus
• Sambutoxin sensitizes K562/ADR to adrimycin by inhibiting express...
• Advanced therapies on BRAF-mutated and KRAS-mutated metastatic co...
• BCL6 inhibition sensitizes solid tumors to TopoⅡ inhibitors
• LL1, a novel specific STAT3 inhibitor, displays anti-colorectal c...
• Ginkgo biloba exocarp extracts inhibits metastasis and its effect...
• Mitomycin C synergizes with PD-L1 blockade in treatment of non-sm...
• Cryptotanshinone switches target from estrogen receptor α to bre...
• Isoliquiritigenin derivative inhibits tumor initiation and progre...
• RNF6 promotes myeloma cell proliferation and survival by inducing...
• Impact of immune infiltration on tumor development and progression
• 2-DG regain sensitivity of drug resistant colon cancer on 5-FU vi...
• Prospect of combination of anti-PD-1/PD-L1 therapy and other ther...
• Panaxadiol inhibits programmed cell deathligand 1 expression and ...
• Functional studies of matrine as an agent targeting tumors harbor...
• Antiphospholipid autoantibodies promote breast tumor progression ...
• A network-based predictive gene expression signature for recurren...
• 2-phenyl-3,4-thiadiazole [3,2-α]-pyrimidine-7-one inhibits cell ...
• Daphne-type diterpenes from Daphne linn and their anti-tumor acti...
• Rociletinib(CO-1686) enhanced efficacy of chemotherapeutic agents...
• Aberrant FoxM1 expression increases ASPM transcription and promot...
• Identification of novel epithelial-mesenchymal transition-related...
• Convallatoxin promotes apoptosis and inhibits proliferation throu...
• Anti-tumor and reversing MDR effects of conglobatin a macrolide d...
• Esterified derivate of sinomenine exerts inhibitory effect on gli...
• Overlapping and uniqueroles played by ROCK1 and 2 in modulation o...
• A novel nanoparticle drug delivery system:tumor-exosome encapsula...
• 偶氮鎓二醇盐衍生物抑制肝癌细胞增殖的机制
• NO供体对二乙基亚硝胺诱发大鼠肝癌的抑制作用
• 基于非凋亡性程序性死亡的抗肿瘤研究现状
• ETP类化合物靶向Hsp90-C端抗肿瘤作用以及对其客户蛋白选择性的影响
• 一种新型的靶向BCL9/β-catenin的抗肿瘤和免疫调控的双功能订书肽抑制剂
• 新型靶向eIF4E小分子化合物的合成及抗肿瘤作用机制
• 大肠癌DNA修复通路基因和ABCG2基因的多态性与奥沙利铂化疗的环境因素...
• 非小细胞肺癌亚群的药物靶标研究
• 壁虎活性组分对肝癌HepG2细胞糖代谢影响的机制研究
• 2种小鼠模型用于研究丹参酮ⅡA预防肿瘤细胞肺部的转移
• 肿瘤相关巨噬细胞在卵巢癌微环境中的作用及研究进展
• 乳腺癌耐药细胞通过PGE2促进C/EBPβ与MFG-E8启动子区结合调控巨噬细胞...
• 白头翁有效成分通过调控肿瘤相关巨噬细胞极化干预肿瘤发生发展的机制
• 新型BTK抑制剂对B淋巴瘤细胞系的杀伤活性与功能
• CX3CL1/CX3CR1介导的血小板浸润抑制肝癌生长
• Trichothecin靶向STAT3抑制结肠癌生长转移及作用机制
• 黄瑞香中活性成分DGD抑制肝癌细胞的作用机制
• 氧化白藜芦醇在体内外抑制肝癌细胞转移的机制
• 壁虎超滤组分通过激活Hippo信号通路抑制人肝癌HepG2细胞生长作用
• 仿生杂交膜纳米药物联合光动力治疗和化疗用于食管癌的研究
• 骨肉瘤的化疗进展研究
• 连接蛋白32及细胞缝隙连接对卵巢癌细胞顺铂耐药性的影响
• 去甲肾上腺素对EGFR-TKI耐药性以及Cx32蛋白表达的影响
• 外泌体与乳腺癌CDK4/6抑制剂耐药的关系研究进展
• 白细胞减少症动物模型优化及代谢组学机制
• 壁虎粗多肽诱导SHSY-5Y细胞凋亡的机制研究
• 顺铂联合CD47抗体对食管癌移植瘤小鼠的治疗效果
• 基于网络药理学探讨白头翁抗结直肠癌的作用机制
• 巨噬细胞外泌体促进乳腺癌细胞增殖和转移
• CLDN3棕榈酰化修饰调控卵巢癌恶性进展的机制研究
• 重组免疫毒素bp/CUS的制备及体外抗肿瘤活性测定
• 黄芩素增强细胞缝隙链接的功能进而增加卵巢癌耐药细胞对顺铂的敏感性
• 专题报告和论文摘要_抗炎抗病毒
• Reversible SAHH inhibitor ameliorates psoriasis-like skin inflamm...
• Mechanism of NLRP3 inflammasome modulated hepatocyte pyroptosis i...
• Abnormal DNA methylome in multi-generational inheritance programm...
• Mechanism of AMPK modulated NLRP3 inflammasome activation to indu...
• Preliminary study on liver protection and antioxidant active site...
• Metabolomics approach reveals vital role of Huangqi in Huangqi Ji...
• Anti-pruritic and anti-inflammatory effects of natural verbascosi...
• Dolichosin A, a coumestan isolated from Glycine tabacina, inhibit...
• Therapeutic effects and regulation of gut microbiota by dihydrota...
• Effects of baicalin and geniposide on polarization of BV2 microglia
• Protective effect of isoforskolin in COPD rat model
• MAPKs signaling in 5-LOX pathway-associated inflammatory responses
• CP-25 alleviates rat collagen induced arthritis by regulating T c...
• 甘草酸单铵和盐酸半胱氨酸对酒精和CCl_4诱导的大鼠肝纤维化模型的作用...
• 月见草籽粗提物对致病性枯草芽孢杆菌的抑菌能力
• 肠道菌群通过腺苷A2A受体介导Treg缺失免疫缺陷病
• 血小板促炎的分子机制和干预药物
• 蛇六谷葡苷露聚糖对小鼠巨噬RAW264.7细胞免疫调节作用及机制研究
• CX-10对DSS诱导的小鼠溃疡性结肠炎的作用及其机制
• 人参皂苷Rg1对小鼠急性肝损伤的保护作用
• 铃兰毒苷通过PPARγ/NF-κκB信号通路抑制葡聚糖硫酸钠诱导的小鼠实验...
• 细胞衰老与肾纤维化
• 特发性肺纤维化的炎症机制和新型分子靶标
• 苯甲酰乌头原碱在类风湿关节炎中作用的进展
• 若干天然活性分子对微血管内皮炎症反应的干预作用
• 拟人参皂苷-F11对脂多糖所致急性肺损伤小鼠的保护作用
• 丹参素通过调节Nrf2/HO-1和NF-κκB/IκBα信号通路发挥抗大鼠肝纤维...
• 血管紧张素Ⅱ2型受体及其信号对类风湿关节炎异常活化的滑膜巨噬细胞的...
• 连翘苷通过调控NF-κκB信号途径抑制肝脏星状细胞的活化
• 颈骨康胶囊的活血化瘀及抗炎镇痛作用
• 人羊膜间充质干细胞治疗卵巢早衰的作用和机制
• 专题报告和论文摘要_代谢疾病
• TLR2-deficiency promotes prenatal LPS exposure-induced offspring ...
• Adipocyte-derived exosomal miR-27a induces insulin resistance in ...
• Different lipids remodeling signature demonstrated heterogeneity ...
• Improvement of lipid metabolic profile by natural piperine in hig...
• P7C3-A20, a novel neuroprotective agent, treats fatty liver throu...
• REG3A is a critical regulator involved in tacrolimus-induced toxi...
• Study on hypoglycemic and hypolipidemic effects of Dayi bacterial...
• Study on pharmacodynamics of QiHu preparation for diabetes
• FOXO1 inhibition potentiates ischemic angiogenesis in diabetes vi...
• Free fatty acid-induced H_2O_2 activates TRPM2 to aggravate endot...
• Evodiamine improves lipid profile in high-fat diet-fed mice by fa...
• Puerarin alleviates skeletal muscle atrophy in type 1 diabetic rats
• High glucose changes mitochondrial dynamics in cultured human glo...
• iTRAQ-and LC-MS/MS-based quantitative proteomics reveals potentia...
• 白藜芦醇通过诱导自噬减少肥胖小鼠骨骼肌组织GDF8表达的研究
• 专题报告和论文摘要_新技术新方法
• Fast cell counting of brightfield microscopic images based on dig...
• New indications for FDA-approved drugs: selective inhibition of g...
• 药物靶点鉴定方法学及其在中药活性成分靶点发现中的应用
• 造血干细胞特异性敲除Foxo1促进NK细胞分化和增殖
• 噬菌体展示技术的概况与应用
• 瑞士球结合电针治疗腰椎间盘突出症的研究
• 基于Cite Space的IRAK4研究发展与演进分析(1999～2019)
• 尿酸酶缺失Kunming-DY大鼠的研制
• GABAA受体相关氯离子通道检测方法研究进展
• From older toxic natural products to current drugs and drug candi...
• Screening inhibitory effects of flavonoids isolated from Artemisi...
• 科罗索酸药理作用研究进展
• 第一作者索引
• 《中国药理学与毒理学杂志》简介